Stop sepsis. Save lives.
World Sepsis Day on September 13 is a global initiative to raise public awareness of sepsis, a leading cause of death and disability for millions of people every year. World Sepsis Day was introduced by the Global Sepsis Alliance, a collaborative effort led by various organizations dedicated to increase the knowledge of sepsis.
Sepsis represents a global burden
31,500,000people per year develop sepsis1
5,300,000people die every year1
The WHO resolution on sepsis
In May 2017, the World Health Organization (WHO) approved a resolution aimed at improving prevention, diagnosisand cureof sepsis. The resolution calls for governments and policy makers to improve policies and procedures related to sepsis, with particular focus on prevention of infection and limitation of further spread of antibiotic resistance. The WHO stresses the importance of raising public awareness of sepsis through proper communication of symptoms, causes and possible outcomes.
Sepsis is associated with a high mortality
The Surviving Sepsis Campaign (SSC) guidelines were published with the aim of improving outcome by standardizing the diagnosis and treatment of sepsis and septic shock. Early diagnosis, aggressive resuscitation, adequate antibiotic therapy, source control and organ support are the key elements of sepsis management2. Despite the development of the guidelines, mortality from sepsis and septic shock remains unacceptable high3. Patients with refractory septic shock, defined as requirement for dopamine >15 μg/kg/min. or norepinephrine/epinephrine >0.25 μg/kg/min. to maintain mean blood pressure above 65 mmHg4, present with a higher mortality5.
Did you know that…
- Sepsis is the primary cause of death from infection
- Sepsis is the most expensive condition treated in hospitals
- Sepsis kills ten times more than heart attack
Moreover, the incidence of sepsis is increasing due to:
- Severe increase in multidrug-resistant Gram-negative bacteria
- Aging population with more comorbidities
- More aggressive surgical and medical interventions
- Fleischmann C, Scherag A, Adhikari NK, et al.: Assessment of Global Incidence and Mortality of Hospital-treated Sepsis. Current Estimates and Limitations. American journal of respiratory and critical care medicine.193:259-272, 2016. (Pubmed)
- Rhodes A, Evans LE, Alhazzani W, et al.: Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016. Intensive care medicine.2017. (Pubmed)
- Shankar-Hari M, Phillips GS, Levy ML, et al.: Developing a new definition and assessing new clinical criteria for septic shock: For the third international consensus definitions for sepsis and septic shock (sepsis-3). JAMA : the journal of the American Medical Association.315:775-787, 2016. (Pubmed)
- Annane D, Bellissant E, Cavaillon JM: Septic shock. Lancet.365:63-78, 2005. (Pubmed)
- Bassi E, Park M, Azevedo LC: Therapeutic strategies for high-dose vasopressor-dependent shock. Critical care research and practice.2013:654708, 2013. (Pubmed)